Nipro is continuously committed to bringing you an innovative portfolio of superior quality products. See how we combine innovation and automation to bring you the ultimate in pre-fillable syringe quality.

Laser assisted cutting of glass
Quality issues are a serious challenge!

Rejected starting material, filling line interruptions, recalled finished products – these are serious matters for patients, pharmaceutical companies, and manufacturers alike.

Glass cutting technology in the converting process of pre-fillable syringes (PFS) has a major influence on:

  • Glass particles generation
    the more particles, the higher the risk of particles remaining inside the syringe
  • Mechanical finger flange stability
    if not strong enough, risk of breakage of finger flanges during Fill Finish operations
  • The consistency of syringe flange dimensions
    if inconsistent,  potential problems integrating a syringe into an auto-injection device
It is clear that demands for the quality and integrity of packaging systems are on the rise. The selection and qualification of materials should include a risk assessment during the development phases in close communication with the packaging manufacturers.
Matteo Falgari, Sales Director EMEA

THE SOLUTION WE OFFER YOU

Nipro addresses these influences by implementing an innovative technology of laser-based glass cutting in the converting process of Nipro PFS.

Improved Total Cost of Ownership
  • Less risk of rejections at Fill-Finish sites as a result of fewer particles¹
  • Lower risk of finger flange breakages during Fill-Finish operations due to increased mechanical flange stability
  • Lower risk of market recalls thanks to fewer glass particulates or device functional failures
     
Enhanced Patient Safety
  • Lower risk of glass particulates inside PFS
  • Safer drug delivery devices by virtue of increased finger flange stability
     
Optimized Integration between Auto-Injection Devices and PFS
  • Smoother assembly operations as a result of tighter dimensional parameters for finger flanges

STUDY RESULTS¹

Glass Particles
  • Sub-visible range: -62%
    Significant reduction of glass sub visible particles with Nipro laser-based cut compared to traditional cut
     

  • Visible range: -100%
    No visible particles found with Nipro laser-based cutting
     
Finger Flanges (1 ml long syringe)
  • Dimensional accuracy (thickness): 1.85 mm ±0.1 mm
    More uniform finger flange thickness with Nipro laser-based cut versus traditional cut (1.67 mm +0.3 / -0.2 mm)
     
  • Strength: AVG: +40% NM | MIN: +57% NM
    Strength of finger flanges substantially improved with laser-based cut compared to traditional cut


1 Source: Study performed in collaboration with Centre for glass investigations and environmental analysis