Nipro is continuously committed to bringing you an innovative portfolio of superior quality products. See how we combine innovation and automation to bring you the ultimate in pre-fillable syringe quality.

Laser assisted cutting of glass
Quality issues are a serious challenge!

Rejected starting material, filling line interruptions, recalled finished products – these are serious matters for patients, pharmaceutical companies, and manufacturers alike.

Glass cutting technology in the converting process of pre-fillable syringes (PFS) has a major influence on:

  • Glass particles generation
    the more particles, the higher the risk of particles remaining inside the syringe
  • Mechanical finger flange stability
    if not strong enough, risk of breakage of finger flanges during Fill Finish operations
  • The consistency of syringe flange dimensions
    if inconsistent,  potential problems integrating a syringe into an auto-injection device
It is clear that demands for the quality and integrity of packaging systems are on the rise. The selection and qualification of materials should include a risk assessment during the development phases in close communication with the packaging manufacturers.
Matteo Falgari, Sales Director EMEA


Nipro addresses these influences by implementing an innovative technology of laser-based glass cutting in the converting process of Nipro PFS.

Improved Total Cost of Ownership
  • Less risk of rejections at Fill-Finish sites as a result of fewer particles¹
  • Lower risk of finger flange breakages during Fill-Finish operations due to increased mechanical flange stability
  • Lower risk of market recalls thanks to fewer glass particulates or device functional failures
Enhanced Patient Safety
  • Lower risk of glass particulates inside PFS
  • Safer drug delivery devices by virtue of increased finger flange stability
Optimized Integration between Auto-Injection Devices and PFS
  • Smoother assembly operations as a result of tighter dimensional parameters for finger flanges


Glass Particles
  • Sub-visible range: -62%
    Significant reduction of glass sub visible particles with Nipro laser-based cut compared to traditional cut

  • Visible range: -100%
    No visible particles found with Nipro laser-based cutting
Finger Flanges (1 ml long syringe)
  • Dimensional accuracy (thickness): 1.85 mm ±0.1 mm
    More uniform finger flange thickness with Nipro laser-based cut versus traditional cut (1.67 mm +0.3 / -0.2 mm)
  • Strength: AVG: +40% NM | MIN: +57% NM
    Strength of finger flanges substantially improved with laser-based cut compared to traditional cut

1 Source: Study performed in collaboration with Centre for glass investigations and environmental analysis