Reliable Filling and Stable Storage of Drug Products

As a premier producer of high-quality pre-fillable glass syringes designed for the pharmaceutical industry, Nipro provides precise solutions tailored to meet the specific requirements of standard and complex drug products. Whether it is for vaccines, biologics, or other sensitive drug products, Nipro’s D2F™ pre-fillable glass syringes offer a trusted solution that pharmaceutical companies can rely on.

Drawing upon extensive expertise in glass manufacturing, Nipro delivers syringes that seamlessly integrate into the intricate workflows of pharmaceutical production. They contribute to smooth fill-finish operations, stable storage and smooth administrations.

Your syringes are manufactured in a state-of-the-art plant which is controlled by strict quality systems, encompassing ISO 15378, ISO 9001, ISO 45001, ISO 14001, and IS0 50001 certifications.

Our comprehensive support infrastructure, including regulatory guidance, technical assistance, and laboratory facilities, promptly attends to queries and ensures successful partnerships.

Specifications

Range - Glass Barrel

Volume	Outer diameter	Flange - round	Flange - small round	Flange - cut
0.5 ml	6.85 mm	√	√	√
1 ml long	8.15 mm	√	√	√
1 ml std.	10.85 mm	√	√	√
1.25 ml	10.85 mm	√	√	√
1.5 ml	10.85 mm	√	√	√
2.25 ml	10.85 mm	√	√	√

Range - Needle type

Outer diameter	Length	Wall type	Bevel type
23G \| 0.6 mm	1" \| 25 mm	Regular	3-bevel
25G \| 0.5 mm	⁵⁄₈" \| 16 mm	Regular	3-bevel
25G \| 0.5 mm	1" \| 25 mm	Regular	3-bevel
27G \| 0.4 mm	½" \| 12.7 mm	Regular	V-bevel
27G \| 0.4 mm	½" \| 12.7 mm	Thin	V-bevel
29G \| 0.33 mm	½" \| 12.7 mm	Thin	V-bevel

Range - Components

Closure	Plunger rod	Plunger stopper	Safety system	Backstop
Soft needle shield	Transparent	Standard	West - NovaGuard®	Transparent
Rigid needle shield	Color	Coated	Schreiner MediPharm - Needle Trap®	Color
		Bagged \| RTU	Nemera - Safe'N'Sound®

Suppliers of rubber components: Aptar, West, Datwyler

Sterile Packaging Solution

Nipro manufactures D2F™ syringes in technologically advanced production sites that are certified according to ISO 9001, ISO 15378, ISO 14001, and ISO 50001. Our fully automated cleaning and packaging process takes place in an ISO 7/ISO 8 cleanroom with 100% monitoring under laminar air flow.

Key-technologies:

Less particles: Tub and test are cleaned by ionized air before entering the D2F™ process
Optimal entrance of tub on filling line: 100%, In-line camera inspected (nest full, closure on syringe present, correct Tyvek® placement)
High cosmetics quality for less risk of rejects at final inspection: No glass-to-glass contact in tub
Visual control that tubs were sterilized: ETO indicator on tub (color change from blue to green after ETO exposure)

Nipro’s D2F™ packaging design is a smart, efficient choice that enables immediate and direct use on the filling line. In essence, Direct-to-Fill.

Tub insert	Breather bag	Outer box	Pallet	Slip sheet insert
Single (Tyvek)	Single	Cardboard	Wooden (treated)	Optional
Double (Tyvek)	Double	PP-well	Plastic

Downloads

D2F Packaging for Pre-fillable Syringes

Pharmaceutical Packaging

Brochures

Download

D2F Pre-fillable Glass Syringes

Pharmaceutical Packaging

Brochures

Download

Frequently Asked Questions (FAQs)

What does "PFS" stand for?

"PFS" stands for "Pre-Filled Syringe." A pre-filled syringe is a type of medical device used for the storage and administration of medications. It consists of a syringe barrel pre-filled with a specific dosage of medication, a plunger, and needle or needle cap. Pre-filled syringes are designed to be used immediately without requiring additional preparation or assembly by healthcare professionals.

What are the advantages of pre-filled syringes?

Pre-filled syringes offer various advantages when compared to other container types:

Accurate dosing
Convenience and ease of use
Reduced risk of contamination
Improved patient safety
Minimized medication wastage
No reconstitution is required

Do silicone oil-free prefilled glass syringes exist?

Yes, silicone oil-free syringes do exist. These syringes are manufactured using materials and processes that eliminate the presence of silicone oil, which can be a concern for certain pharmaceutical applications.