Optimal choice for highly sensitive/Biotech drugs
Nipro eNhance syringes are specially designed to meet the demanding quality requirements of large molecule / biotech drugs.
Improved drug-container compatibility
Highly sensitive drugs, due to their nature, run higher risks of interacting with primary container materials (e.g. pH shift, protein aggregation, delamination). Several syringe specifications are inspected during the production process to ensure drug-container compatibility.
Smooth integration into auto-injection devices
High drug viscosity, product differentiation, and end-user preference lead to an increased use of combination products. Several syringe parameters ensure reliable integration and a seamless functioning of auto-injection devices.
Optimized processability for minimal drug loss
When filling high value drug products, each unit counts. Controlling specific syringe attributes will contribute to smooth fill-finish operations, in terms of reducing the risk of breakage, leakage, and rejections during final inspection.
eNhance syringes are manufactured on state of the art lines equipped with a large number of 100 % in-line camera inspection, ensuring that each syringe meets narrow dimensional and cosmetic specifications. D2F™ (Direct-to-Fill) sterile packaging is compatible with all major filling lines. The packaging process takes place in an ISO 7/8 clean room environment and is fully automated.
- Improved drug-container compatibility
- Smooth integration into auto-injection devices
- Optimized processability for minimal drug loss
Specifications
Range - Tubing & Barrel
| Volume | Outer diameter | Luer slip | Luer lock | Staked needle | Flange - round | Flange - small round | Flange - cut | Shoulder - round | Shoulder - flat |
|---|---|---|---|---|---|---|---|---|---|
| 0.5 ml | 6.35 mm | √ | √ | √ | √ | √ | √ | ||
| 1 ml long | 8.15 mm | √ | √ | √ | √ | √ | √ | ||
| 1 ml std. | 10.85 mm | √ | √ | √ | √ | √ | √ | ||
| 1.25 ml | 10.85 mm | √ | √ | √ | √ | √ | |||
| 1.5 ml | 10.85 mm | √ | √ | √ | √ | √ | |||
| 2.25 ml | 10.85 mm | √ | √ | √ | √ | √ | √ | ||
| 3 ml | 10.85 mm | √ | √ | √ | √ | √ |
*only available in eNable
Range - Needle type
| Outer diameter | Length | Wall type | Bevel type |
|---|---|---|---|
| 25G | 0.5 mm | ⁵⁄₈" | 16 mm | Regular wall | 3-bevel |
| 27G | 0.4 mm | ½" | 12.7 mm | Thin wall | V-bevel |
| 29G | 0.33 mm | ½" | 12.7 mm | Thin wall | V-bevel |
Range - Closure
| For staked needle | For luer lock |
|---|---|
| Rigid needle shield | LInC™ (Luer Lock Integrated Cap) |
| V-OVS |
Suppliers: Aptar Stelmi, Datwyler, West, Vetter
Range - Plunger stopper & Plunger rod & Safety system
| Plunger rod | Plunder stopper | Safety system |
|---|---|---|
| For syringes from 0.5 to 3ml | Standard | Safe'N'Sound |
| Transparent / Color | Coated |
Suppliers: Aptar Stelmi, Datwyler, West, Nemera, Nipro
D2F™ (Direct-To-Fill)
Sterile packaging solution
| Tub insert | Breather bag | Outer box | Pallet | Slip sheet insert | Batch size |
|---|---|---|---|---|---|
| Single (Tyvek®)* | Single* | PP-well* | Wooden (treated)* | Optional | 4 pallets* |
| Double (Tyvek®) | Double | Plastic | 16 pallets |
*Standard
Downloads
D2F Pre-fillable Glass Syringes - Technology - Laser Based Cutting
Pharmaceutical Packaging
Brochures
Pre-fillable Syringes - Technology - Laser Based Cutting & X-Ray inspection
Pharmaceutical Packaging
Whitepapers
D2F Pre-fillable Glass Syringes with LInC (Luer Lock Integrated Cap)
Pharmaceutical Packaging
Brochures
Frequently Asked Questions (FAQs)
What does "PFS" stand for?
"PFS" stands for "Pre-Filled Syringe." A pre-filled syringe is a type of medical device used for the storage and administration of medications. It consists of a syringe barrel pre-filled with a specific dosage of medication, a plunger, and needle or needle cap. Pre-filled syringes are designed to be used immediately without requiring additional preparation or assembly by healthcare professionals.
What are the advantages of pre-filled syringes?
Pre-filled syringes offer various advantages when compared to other container types:
- Accurate dosing
- Convenience and ease of use
- Reduced risk of contamination
- Improved patient safety
- Minimized medication wastage
- No reconstitution is required
Do silicone oil-free prefilled glass syringes exist?
Yes, silicone oil-free syringes do exist. These syringes are manufactured using materials and processes that eliminate the presence of silicone oil, which can be a concern for certain pharmaceutical applications.
Need help?
Get in touch
For information regarding Nipro products, services, and resource material:
| Give us a call +32 15 263 500 |
E-mail us pharmapackaging@nipro-group.com |
| Submit a detailed inquiry: Contact per expertise |
View our manufacturing locations: Our global network |